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Trends Cell Biol. 2005 May;15(5):251-8.

RNA silencing and genome regulation.

Author information

1
Wellcome Trust Centre for Cell Biology, 6.34 Swann Building, King's Buildings, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK.

Abstract

Closely related RNA silencing phenomena such as posttranscriptional and transcriptional gene silencing (PTGS and TGS), quelling and RNA interference (RNAi) represent different forms of a conserved ancestral process. The biological relevance of these RNA-directed mechanisms of silencing in gene regulation, genome defence and chromosomal structure is rapidly being unravelled. Here, we review the recent developments in the field of RNA silencing in relation to other epigenetic phenomena and discuss the significance of this process and its targets in the regulation of modern eukaryotic genomes.

PMID:
15866029
DOI:
10.1016/j.tcb.2005.03.006
[Indexed for MEDLINE]

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