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Trends Cell Biol. 2005 May;15(5):231-3.

Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis.

Author information

1
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK. vvanoost@staffmail.ed.ac.uk

Abstract

To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.

PMID:
15866025
DOI:
10.1016/j.tcb.2005.03.003
[Indexed for MEDLINE]

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