Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Cancer. 2005 May;5(5):355-66.

Ovarian cancer metastasis: integrating insights from disparate model organisms.

Author information

1
Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Abstract

Despite considerable efforts to improve early detection, and advances in chemotherapy, metastasis remains a major challenge in the clinical management of ovarian cancer. Studies of new murine models are providing novel insights into the pathophysiology of ovarian cancer, but these models are not readily amenable to genetic screens. Genetic analysis of border-cell migration in the Drosophila melanogaster ovary provides clues that will improve our understanding of ovarian cancer metastasis at the molecular level, and also might lead to potential therapeutic targets.

PMID:
15864277
DOI:
10.1038/nrc1611
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center