Format

Send to

Choose Destination
Cytokine Growth Factor Rev. 2005 Apr;16(2):215-20. Epub 2005 Mar 23.

Fibroblast growth factor homologous factors: evolution, structure, and function.

Author information

1
Department of Biological Sciences, Hunter College of City University, New York, NY 10021, USA.

Abstract

Fibroblast growth factor homologous factors (FHFs) bear strong sequence and structural similarity to fibroblast growth factors (FGFs). However, the biochemical and functional properties of FHFs are largely, if not totally, unrelated to those of FGFs. Whereas FGFs function through binding to the extracellular domains of FGF receptors (FGFRs), FHFs bind to intracellular domains of voltage-gated sodium channels (VGSCs) and to a neuronal MAP kinase scaffold protein, islet-brain-2 (IB2). These findings demonstrate the remarkable functional adaptability during evolution of the FGF gene family. FHF gene mutations in mice result in a range of neurological abnormalities, and at least one of these anomalies, cerebellar ataxia, is linked to FHF mutations in humans. This article reviews the sequences and structure of FHFs, along with our still limited understanding of FHF function.

PMID:
15863036
PMCID:
PMC3212846
DOI:
10.1016/j.cytogfr.2005.02.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center