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Cytokine Growth Factor Rev. 2005 Apr;16(2):151-8. Epub 2005 Mar 26.

FGF signaling in flies and worms: more and more relevant to vertebrate biology.

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Yale University School of Medicine, Department of Genetics, I-354 SHM, P.O. Box 208005, New Haven, CT 06520-8005, USA.


FGF signaling in the invertebrate model systems Drosophila melanogaster and Caenorhabditis elegans was initially most obviously involved in cell motility events. More recently, however, FGFs and FGF signaling in these systems have been shown to affect many additional cellular processes. This recent work has shown that the pleiotropies of these FGF receptors resemble those of their vertebrate counterparts, and, in many cases, serve as excellent models for understanding the fundamental molecular mechanisms controlling these events.

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