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FEBS Lett. 2005 May 9;579(12):2576-82. Epub 2005 Apr 8.

Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells.

Author information

1
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Japan.

Abstract

Connective tissue growth factor (CTGF) is induced by transforming growth factor-beta (TGF-beta) via Smad activation in mesangial cells. We recently reported that sphingosine 1-phosphate (S1P) induces CTGF expression in rat cultured mesangial cells. However, the mechanism by which S1P induces CTGF expression is unknown. The present study revealed that S1P-induced CTGF expression is mediated via pertussis toxin-insensitive pathways, which are involved in the activation of small GTPases of the Rho family and protein kinase C. We also showed by luciferase reporter assays and chromatin immunoprecipitation that S1P induces CTGF expression via Smad activation as TGF-beta does.

PMID:
15862293
DOI:
10.1016/j.febslet.2005.03.073
[Indexed for MEDLINE]
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