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Nat Rev Genet. 2005 May;6(5):376-88.

Genetics of Crohn disease, an archetypal inflammatory barrier disease.

Author information

1
Institute for Clinical Molecular Biology, Center for Conservative Medicine, Christian-Albrechts-University Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany. s.schreiber@mucosa.de

Abstract

Chronic inflammatory disorders such as Crohn disease, atopic eczema, asthma and psoriasis are triggered by hitherto unknown environmental factors that function on the background of some polygenic susceptibility. Recent technological advances have allowed us to unravel the genetic aetiology of these and other complex diseases. Using Crohn disease as an example, we show how the discovery of susceptibility genes furthers our understanding of the underlying disease mechanisms and how it will, ultimately, give rise to new therapeutic developments. The long-term goal of such endeavours is to develop targeted prophylactic strategies. These will probably target the molecular interaction on the mucosal surface between the products of the genome and the microbial metagenome of a patient.

PMID:
15861209
DOI:
10.1038/nrg1607
[Indexed for MEDLINE]

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