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Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):276-9. Epub 2005 Jan 8.

Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells.

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Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK.


Mineralocorticoid receptor expression is increased following neuronal injury, and this is associated with increased neuronal survival. Here we demonstrate a causal link between overexpression of MR in PC12 cells and protection against death induced by staurosporine and oxygen-glucose deprivation. This survival effect is abrogated by MR antagonism. Drugs which upregulate MR may form the basis for a novel therapeutic approach in conditions such as stroke and head injury.

[Indexed for MEDLINE]

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