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Brain Res Mol Brain Res. 2005 Apr 27;135(1-2):276-9. Epub 2005 Jan 8.

Overexpression of the mineralocorticoid receptor protects against injury in PC12 cells.

Author information

1
Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK. m.lai@ed.ac.uk

Abstract

Mineralocorticoid receptor expression is increased following neuronal injury, and this is associated with increased neuronal survival. Here we demonstrate a causal link between overexpression of MR in PC12 cells and protection against death induced by staurosporine and oxygen-glucose deprivation. This survival effect is abrogated by MR antagonism. Drugs which upregulate MR may form the basis for a novel therapeutic approach in conditions such as stroke and head injury.

[Indexed for MEDLINE]

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