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J Med Chem. 2005 May 5;48(9):3095-8.

Discovery of a beta-MSH-derived MC-4R selective agonist.

Author information

1
Lilly Research Laboratories, A Division of Eli Lilly and Co., Lilly Corporate Center, Indianapolis, Indiana 46285, USA. j.mayer@lilly.com

Abstract

A series of novel, disulfide-constrained human beta-melanocyte stimulating hormone (beta-MSH)-derived peptides were optimized for in vitro melanocortin-4 receptor (MC-4R) binding affinity, agonist efficacy, and selectivity. The most promising of these, analogue 18, was further studied in vivo using chronic rat food intake and body weight models.

PMID:
15857110
DOI:
10.1021/jm0501432
[Indexed for MEDLINE]

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