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Nat Neurosci. 2005 May;8(5):579-84.

Hypothalamic sensing of fatty acids.

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1
Department of Medicine and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Abstract

Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

PMID:
15856066
DOI:
10.1038/nn1456
[Indexed for MEDLINE]
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