Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2005 May;49(5):1770-4.

Biphasic effects of geranylgeraniol, teprenone, and phytol on the growth of Staphylococcus aureus.

Author information

1
Department of Microbiology, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. inoue@ac.shoyaku.ac.jp

Abstract

We examined the antibacterial activities against Staphylococcus aureus of three diterpenes, namely, geranylgeraniol, teprenone, and phytol, by using a broth dilution with shaking method to identify the effects of diterpenes with long aliphatic carbon chains. We also performed time-kill assays and measured the leakage of K(+) ions from bacterial cells in response to these diterpenes. The diterpenes used inhibited the growth of S. aureus at concentrations of 0.15 microg/ml, as determined by damage to the cell membranes, and had clear bactericidal activity. However, the inhibitory effects of the diterpenes decreased when the concentration of each was raised above a certain level. The diterpenes tested in this study appeared to have both growth-inhibitory and growth-accelerating effects, and the net effect of each depended on its concentration.

PMID:
15855494
PMCID:
PMC1087616
DOI:
10.1128/AAC.49.5.1770-1774.2005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center