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Neurosci Lett. 2005 May 20-27;380(1-2):99-104. Epub 2005 Feb 1.

Prognostic value of median and tibial somatosensory evoked potentials in acute stroke.

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Stroke Unit, Department of Neurology, Medical University of Pleven, Georgi Kochev str. 8A, Pleven 5800, Bulgaria.


The predictive values of early somatosensory evoked potentials (SSEPs) for the functional outcome after stroke are investigated. Ninety-four stroke patients (mean age: 61.2, S.D.: 11.8) with CT confirmed diagnoses of middle cerebral artery (MCA) infarction in 71 and supratentorial intracerebral hemorrhage in 23. Median and tibial SSEPs were recorded within 3 days of onset. SSEP parameters were compared to motor (MRC) and functional ability (Barthel index) followed up at 1, 3, 6 and 12 months. Upper limb MRC remains the strongest single predictor of functional outcome, determining 54.3% of Barthel index value at 12 months. The highest predictive value among SSEP parameters has N20-P25 amplitude ratio-34.5%. Combined application of upper limb MRC and N20-P25 amplitude ratio provided significantly stronger prognostic information-66%. Combined assessment of SSEP parameters and muscle power in acute stroke considerably improves prediction of functional outcome.

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