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Retrovirology. 2005 Apr 26;2:27.

Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL).

Author information

1
Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. mmatsuok@virus.kyoto-u.ac.jp

Abstract

The clinical entity of adult T-cell leukemia (ATL) was established around 1977, and human T-cell leukemia virus type 1 (HTLV-I) was subsequently identified in 1980. In the 25 years since the discovery of HTLV-I, HTLV-I infection and its associated diseases have been extensively studied, and many of their aspects have been clarified. However, the detailed mechanism of leukemogenesis remains unsolved yet, and the prognosis of ATL patients still poor because of its resistance to chemotherapy and immunodeficiency. In this review, I highlight the recent progress and remaining enigmas in HTLV-I infection and its associated diseases, especially ATL.

PMID:
15854229
PMCID:
PMC1131926
DOI:
10.1186/1742-4690-2-27
[Indexed for MEDLINE]
Free PMC Article

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