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Curr Med Chem. 2005;12(7):795-805.

Fluorescence imaging of tumors in vivo.

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  • 1Molecular Biosensor and Imaging Center, Department of Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.


We review recent progress in tumor imaging in vivo using fluorescent tags, highlight the problems of fluorescence imaging in small animals, discuss recent advances in near-infrared fluorochromes and quantum dots, and point to some future possibilities. GFP-based fluorescence imaging is briefly discussed. The authors believe that improvements in near-infrared fluorochromes are required to enable practical imaging in tissues at centimeter depths.

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