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Curr Pharm Des. 2005;11(10):1223-36.

Inflammatory-mediated injury and repair in the traumatically injured spinal cord.

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The Neuroscience Graduate Studies Program, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA.


Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.

[Indexed for MEDLINE]

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