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J Am Chem Soc. 2005 May 4;127(17):6148-9.

Enzymatic approach to unnatural glycosides with diverse aglycon scaffolds using glycosyltransferase VinC.

Author information

1
Department of Chemistry and Department of Chemistry and Materials Science, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.

Abstract

Glycosyltransferase VinC was explored for a construction of glycoside libraries using dTDP-vicenisamine and structurally unrelated unnatural aglycons, and new unnatural vicenisaminides were successfully constructed. Structural elements of aglycon recognition by VinC were proposed by modeling studies and were confirmed by the success of transglycosylation upon a designed aglycon.

PMID:
15853301
DOI:
10.1021/ja042848j
[Indexed for MEDLINE]

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