Format

Send to

Choose Destination
Neurology. 2005 Apr 26;64(8):1431-4.

Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment.

Author information

1
Memory and Aging Center, Department of Neurology, UCSF, San Francisco, CA 94143-1207, USA. adam.boxer@memory.ucsf.edu

Abstract

An elevated serum homocysteine level is a risk factor for the development of cognitive impairment. Reported is a late-onset case of hyperhomocystinemia due to a vitamin B12 metabolic deficit (cobalamin C) with cognitive impairment, primarily in frontal/executive function. After homocysteine-lowering therapy, the patient's functional and neuropsychological status improved in conjunction with a decrease in leukoariosis on his MRI scan. These findings suggest that homocysteine-related cognitive impairment may be partially reversible.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center