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Neuron. 2005 Apr 21;46(2):161-3.

New exchanges in eph-dependent growth cone dynamics.

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Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4.


The Eph receptor tyrosine kinases and their ephrin ligands play a pivotal role during axon pathfinding and neural circuitry formation. A prominent way in which Eph receptors sculpt cellular morphology is by remodeling the actin cytoskeleton and the surrounding plasma membrane through the regulation of Rho family GTPases. Two articles in this issue of Neuron (Sahin et al. and Cowan et al.) shed light on how Eph receptors recruit guanine nucleotide exchange factors for Rho family GTPases to modulate growth cone dynamics.

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