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Clin Lab Med. 2005 Jun;25(2):259-77.

Molecular genetics of familial renal cell carcinoma syndromes.

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1
The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Abstract

RCC represents a group of clinically and genetically diverse diseases. Familial RCC syndromes, although rare, provide an invaluable model to study the molecular mechanisms of renal carcinogenesis. Many causative oncogenes and tumor suppressor genes have been identified and it is now possible to identify the affected individuals and carriers by genetic testing. Understanding of the molecular pathways of these genes will have a significant impact on the diagnosis and treatment of familial and sporadic RCC.

PMID:
15848736
DOI:
10.1016/j.cll.2005.01.003
[Indexed for MEDLINE]

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