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Plast Reconstr Surg. 1992 Jun;89(6):1092-7.

Cyclophosphamide-induced neutropenia: effect on postischemic skin-flap survival.

Author information

1
Microsurgical Research Laboratory, Royal Victoria Hospital, Montreal, P.Q., Canada.

Abstract

In a blinded study, 24 pigs were randomized to a 5-day preoperative treatment regimen of cyclophosphamide (n = 12) or placebo (n = 12). At operation, buttock cutaneous and latissimus dorsi myocutaneous flaps were created and then subjected to 6 hours of global ischemia. After 24 hours of reperfusion, flap skin and muscle survivals were determined. All cyclophosphamide-treated animals were rendered neutropenic (less than 500 neutrophils/mm3 of peripheral blood). The results show that neutropenia had no effect on postischemic buttock cutaneous flap survival. In contrast, cyclophosphamide-induced neutropenia demonstrated a significant protective effect on postischemic latissimus dorsi myocutaneous flap survival. This study further implicates the neutrophil as a significant factor in the mediation of ischemia/reperfusion injury of myocutaneous flaps.

PMID:
1584869
[Indexed for MEDLINE]

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