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FEBS Lett. 2005 Apr 25;579(11):2355-8.

The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin.

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MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, UK.


The G6b gene, located in the human Major Histocompatibility Complex, encodes a receptor of the immunoglobulin (Ig) superfamily. In this study, we show using a variety of techniques that the extracellular domain of the G6b protein, containing a single Ig-like domain, binds to heparin with high affinity. In an ELISA assay, this binding was displaceable with soluble heparin with an IC50 value of approximately 0.5 microg/ml. Other sulfated glycans showed weaker or no competition. The observed interaction between G6b and heparin is strongly salt dependent suggesting a mainly electrostatic interaction. Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand.

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