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Am J Obstet Gynecol. 2005 Apr;192(4):1179-86.

Experimental intrauterine Ureaplasma infection in sheep.

Author information

1
School of Women's and Infants' Health, The University of Western Australia, Perth, Australia. tmoss@cyllene.uwa.edu.au

Abstract

OBJECTIVE:

Prenatal Ureaplasma spp exposure is associated with preterm birth and modulates the neonates' susceptibility to respiratory distress syndrome and bronchopulmonary dysplasia. We hypothesized that intra-amniotic ureaplasmas would cause lung inflammation and alter fetal lung development.

STUDY DESIGN:

Pregnant ewes bearing singleton fetuses were given an intra-amniotic injection of 20 x 10 6 CFUs of U parvum (serovar 3) or vehicle, either 1, 3, 6, or 10 weeks before the delivery of preterm lambs at 124 days of gestation (n = 4-10 per group) for evaluation of inflammation and fetal lung maturation.

RESULTS:

Ureaplasmas were recovered from amniotic and fetal lung fluids after intra-amniotic injection. Body weight and umbilical arterial pH were reduced by Ureaplasma exposure for 10 weeks ( P < .05). Ureaplasmas caused progressive lung inflammation and improvements in lung function that were associated with increased surfactant lipids (control, 0.13 +/- 0.02 micromol/kg; 10 weeks of Ureaplasma exposure, 7.43 +/- 3.0 micromol/kg; P < .001) and surfactant protein messenger RNA expression.

CONCLUSION:

Long-term exposure to ureaplasmas in amniotic fluid alters ovine fetal development.

PMID:
15846199
DOI:
10.1016/j.ajog.2004.11.063
[Indexed for MEDLINE]

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