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Cell Cycle. 2005 May;4(5):672-4. Epub 2005 May 25.

Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation.

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1
Cancer Research UK, London Research Institute, South Mimms, Herts, UK.

Abstract

In human cells, homologous recombination (HR) provides an accurate mechanism for the repair of DNA double-strand breaks caused by replication fork breakdown or DNA damaging agents. HR also plays a role in the maintenance of eukaryotic telomeres; cells defective in the recombinational repair proteins RAD51D or RAD54 exhibit telomere shortening and end-to-end chromosome fusions. Here we discuss the way in which HR contributes to telomere protection and elongation in mammalian cells. Understanding the mechanisms by which HR promotes telomere maintenance has important implications for genomic stability and tumorigenesis.

PMID:
15846103
DOI:
10.4161/cc.4.5.1689
[Indexed for MEDLINE]
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