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Toxicol Appl Pharmacol. 2005 May 1;204(3):355-60.

The dopamine transporter: role in neurotoxicity and human disease.

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1
Department of Psychiatry and Behavioral Neuroscience, Pharmacology, and Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA. mbannon@med.wayne.edu

Abstract

The dopamine transporter (DAT) is a plasma membrane transport protein expressed exclusively within a small subset of CNS neurons. It plays a crucial role in controlling dopamine-mediated neurotransmission and a number of associated behaviors. This review focuses on recent data elucidating the role of the dopamine transporter in neurotoxicity and a number of CNS disorders, including Parkinson disease, drug abuse, and attention deficit hyperactivity disorder (ADHD).

PMID:
15845424
DOI:
10.1016/j.taap.2004.08.013
[Indexed for MEDLINE]
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