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Org Lett. 2005 Apr 28;7(9):1719-22.

DTPA-bisamide-based MR sensor agents for peroxidase imaging.

Author information

1
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.

Abstract

[reaction: see text] The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H(2)O(2) pair resulting in a net increase in longitudinal (R1) relaxivity.

PMID:
15844889
DOI:
10.1021/ol050208v
[Indexed for MEDLINE]

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