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Mol Cell Biochem. 1992 Mar 25;110(2):169-73.

Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin.

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Department of Medicine, George Washington University Medical Center, Washington, DC 20037.


We have developed two rodent models of diet-induced magnesium-deficiency in which histologically defined cardiac lesions can be induced within two to three weeks. During the development of these lesions, the magnesium-deficient animals exhibit circulating cytokine levels which are indicative of a generalized inflammatory state. Dramatic elevations of the macrophage-derived cytokines, IL-1, IL-6, and TNF-alpha together with significantly elevated levels of the endothelial cell-derived cytokine, endothelin, were detected in the plasma of these animals. We believe that the pathophysiological effects caused by the action of these cytokines may play a role in the promotion of cardiovascular pathology associated with magnesium deficiency.

[Indexed for MEDLINE]

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