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J Clin Invest. 2005 Apr;115(4):813-24.

Melanoma genetics and the development of rational therapeutics.

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1
Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA.

Abstract

Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.

PMID:
15841168
PMCID:
PMC1070435
DOI:
10.1172/JCI24808
[Indexed for MEDLINE]
Free PMC Article
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