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Nat Rev Immunol. 2005 May;5(5):413-20. doi: 10.1038/nri1600.

Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?

Author information

1
Laboratory of Lymphoid Tissue Development, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris, France. geberl@pasteur.fr

Abstract

The intestinal immune system faces an extraordinary challenge from the large numbers of commensal bacteria and potential pathogens that are restrained by only a single layer of epithelial cells. Here, I discuss evidence that the intestinal immune system develops an extensive network of inducible, reversible lymphoid tissues that contributes to the vital equilibrium between the gut and the bacterial flora. I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development.

PMID:
15841100
DOI:
10.1038/nri1600
[Indexed for MEDLINE]

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