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Semin Cell Dev Biol. 2005 Jun;16(3):369-81.

Inhibition of the cell cycle with chemical inhibitors: a targeted approach.

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Laboratory of Molecular Biophysics and Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK.


Genetic links between deregulation of the cell cycle and cancer are well established. There have been significant recent developments both in our understanding of the molecular mechanisms that control cell cycle progression and in methods for protein structure determination at atomic resolution. These advances have allowed the rational design of small molecules that modulate the cell cycle by competing for sites of protein-protein or protein-ATP interactions. There is considerable optimism that these compounds, a selection of which are here reviewed, will become clinically significant drugs.

[Indexed for MEDLINE]

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