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J Am Chem Soc. 2005 Apr 27;127(16):5732-3.

Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging.

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  • 1Department of Chemistry, Yonsei University, Seoul 120-749, Korea.

Abstract

Since the use of magnetic nanocrystals as probes for biomedical system is attractive, it is important to develop optimal synthetic protocols for high-quality magnetic nanocrystals and to have the systematic understanding of their nanoscale properties. Here we present the development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes. This system further led to the development of high-performance nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.

PMID:
15839639
DOI:
10.1021/ja0422155
[PubMed - indexed for MEDLINE]
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