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Curr Opin Struct Biol. 2005 Apr;15(2):171-5.

Macromolecular recognition.

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1
Laboratoire de Biochimie Théorique (CNRS UPR 9080), Institut de Biologie Physico-Chimique, 13 rue Pierre et Marie Curie, Paris 75005, France.

Abstract

Computational methods are being developed both to detect the binding surfaces of individual macromolecules and to predict the structure of binary macromolecular complexes. Speeding up and refining this process has required work on search algorithms, molecular representations and interaction potentials. Although backbone flexibility and solvent effects continue to pose problems, encouraging results have been obtained for both protein-protein and protein-DNA complexes.

PMID:
15837175
DOI:
10.1016/j.sbi.2005.01.018
[Indexed for MEDLINE]
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