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J Neuroimmunol. 2005 May;162(1-2):157-64.

Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms.

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Department of Neurology G03.228, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.


Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS.

[Indexed for MEDLINE]

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