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J Neuroimmunol. 2005 May;162(1-2):89-96.

Autocrine activation of microglia by tumor necrosis factor-alpha.

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1
Department of Neuroimmunology, Institute of Environmental Medicine, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.

Abstract

In the central nervous system (CNS), tumor necrosis factor-alpha (TNF-alpha) derived from activated microglia plays a critical role as an inflammatory mediator. In this study, we examined the function of TNF-alpha as an autocrine mediator in microglial activation. TNF-alpha induced TNF-alpha production by microglia through ligation of TNF receptor 1 (TNFR1). TNF-alpha also increased the production of other inflammatory mediators. The activation of microglia by lipopolysaccharide is partially mediated by microglia-derived TNF-alpha. These findings suggest the existence of a positive feedback loop in the activation of microglia via TNF-alpha. This autocrine loop may be involved in the prolonged activation of microglia.

PMID:
15833363
DOI:
10.1016/j.jneuroim.2005.01.015
[Indexed for MEDLINE]
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