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J Neuroimmunol. 2005 May;162(1-2):43-50.

The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages.

Author information

1
Schepens Eye Research Institute and The Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. awtaylor@vision.eri.harvard.edu

Abstract

Since alpha-MSH suppresses endotoxin-induced inflammation by innate immunity, it is possible that alpha-MSH can suppress the interface between innate and adaptive immunity mediated by TLR4-stimulated macrophages. Endotoxin-stimulated macrophages treated with alpha-MSH are suppressed in nitric oxide and IL-12p70 production, and cannot enhance antigen-stimulated IFN-gamma production by Th1 cells. In macrophages treated with alpha-MSH, the inhibitory molecule IRAK-M is bound to IRAK-1, the proximal intracellular signal molecule of endotoxin-bound TLR4. These results further demonstrate the dynamic contribution of the nervous system, and the role of alpha-MSH in modulating the innate and adaptive immune interface in an inflammatory response.

PMID:
15833358
PMCID:
PMC4698338
DOI:
10.1016/j.jneuroim.2005.01.008
[Indexed for MEDLINE]
Free PMC Article

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