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Dement Geriatr Cogn Disord. 2005;20(1):15-24. Epub 2005 Apr 12.

Do vascular lesions and related risk factors influence responsiveness to donepezil chloride in patients with Alzheimer's disease?

Author information

1
Internal Medicine, Neurology, Showa University Northern Yokohama Hospital, Yokohama, Japan. tfukui@med.showa-u.ac.jp

Abstract

The purpose was to identify vascular influences on the responsiveness to donepezil chloride. The study included 50 untreated probable Alzheimer's disease patients with the Modified Hachinski Ischemic Score <4. We assessed baseline cognitive status using the Revised Hasegawa Dementia Scale (HDS-R), Clinical Dementia Rating (CDR) and the clock drawing test (CDT). The response to 5 mg of donepezil was monitored by the CDT for 12 months. Patients were classified as true responders (TR), unchanged (UC) and non-responders according to changes on the CDT in response to treatment. High HDS-R scores, low CDT scores, low CDR and presence of hypertension (HBP) and periventricular hyperintensities (PVH) predicted a TR- or UC-type outcome. Aggravation of executive function by HBP and/or PVH and its improvement by donepezil may have been detected by the CDT.

PMID:
15832031
DOI:
10.1159/000085069
[Indexed for MEDLINE]

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