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Acta Neurochir Suppl. 2005;92:93-7.

Ozone chemonucleolysis in non-contained lumbar disc herniations: a pilot study with 12 months follow-up.

Author information

1
Unità Funzionale di Chirurgia Spinale c.d.c. Villanova, Florence, Italy. joburic@tin.it

Abstract

STUDY DESIGN:

Prospective case series with six and twelve months follow up.

OBJECTIVE:

To observe clinical and morphological results of the intradiscal ozone chemionucleolysis in patients affected by non-contained lumbar disc herniations.

METHODS:

30 patients were included in the study on the base of precise inclusion and exclusion criteria. The patients were followed on 6 and 12 months period by Visual Analogic Scale (VAS), Roland Morris Disability Questionnaire (RMDQ) and Overall Patient Rating Scale (OPRS). Disc herniation volume morphology was evaluated at 5 months by control MRI scanning.

RESULTS:

Twenty-seven patients (90%) showed a statistically significant improvement in pain (P < 0.001, Wilcoxon test) and function (P < 0.001, Wilcoxon test), on VAS and RMDQ evaluation, respectively. The mean satisfaction with the treatment on OPSR was 79.3%, with 24 patients referring satisfaction equal or greater than 80%. There were no major complications related to the procedure.

CONCLUSIONS:

The results of this study indicate the ozone chemonucleolysis as a possibly effective modality of treatment in patients affected by signs and symptoms of non-contained lumbar disc herniations that have overpassed conservative measures and have not yet fulfilled the indications for open surgical treatment.

PMID:
15830976
[Indexed for MEDLINE]

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