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J Med Chem. 2005 Apr 21;48(8):2756-8.

Discovery of S-phase arresting agents derived from noscapine.

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1
Athersys, Inc., 3201 Carnegie Avenue, Cleveland, Ohio 44115-2634, USA.

Abstract

Analogues of the natural product noscapine were synthesized, and their potential as antitumor agents were examined. The discovery of a novel regio- and stereoselective O-demethylation led to the synthesis of several O-alkylated analogues that induced an unexpected S-phase arrest of mammalian cells. Compound 4a was the most potent analogue inhibiting cell proliferation at an EC(50) of 1.9 microM.

PMID:
15828811
DOI:
10.1021/jm0494220
[Indexed for MEDLINE]
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