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Nano Lett. 2005 Apr;5(4):603-7.

Peptide-conjugated quantum dots activate neuronal receptors and initiate downstream signaling of neurite growth.

Author information

1
Department of Biomedical Engineering, 44 Cummington St., Room 701, Boston University, Boston, Massachusetts 02215, USA. tvu@bme.ogi.edu

Abstract

Quantum dots (QDs) could serve as fluorescent scaffolds for effecting specific physiological and pharmacological responses in cells. Here, we conjugate the peptide ligand betaNGF to QD surfaces, and confirm surface modification and single QD nanostructure using AFM. We show that betaNGF-QDs retain bioactivity, activate TrkA receptors, and initiate neuronal differentiation in PC12 cells. Receptor-evoked activity of QD-immobilized ligands has wide-ranging implications for the development of molecular tools and therapeutics targeted at understanding and regulating cell function.

PMID:
15826094
DOI:
10.1021/nl047977c
[Indexed for MEDLINE]

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