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Neurology. 2005 Apr 12;64(7):1285-7.

Heparin-induced thrombocytopenia in neurologic patients treated with low-molecular-weight heparin.

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Department of Neurology, University Hospital Bonn, Germany.


The authors prospectively studied the risk for immune-mediated heparin-induced thrombocytopenia (HIT) in neurologic patients during administration of low-molecular-weight heparin (LMWH) vs unfractionated heparin (UFH). None of 111 neurologic patients receiving LMWH developed HIT, whereas HIT occurred in 2.5% of 200 patients treated with UFH (p = 0.17). The rate of heparin-induced antibodies in patients treated with LMWH was lower than in patients treated with UFH (1.8 vs 20.5%; p < 0.001).

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