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Curr Biol. 2005 Apr 12;15(7):R249-52.

Sex chromosome inactivation: the importance of pairing.

Author information

1
Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. lee@amber.mgh.harvard.edu

Abstract

In mammals, the process of making sperm is marked by inactivation of sex chromosomes. Why and how does this happen? The answer apparently lies in whether a chromosome finds a pairing partner. Similar mechanisms in mold and worms reveal a surprising and recurrent theme throughout evolution.

PMID:
15823524
DOI:
10.1016/j.cub.2005.03.024
[Indexed for MEDLINE]
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