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Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs.

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Department of Physiology and Pharmacology, Karolinska Institutet, S-17177 Stockholm, Sweden.


Adenosine and its receptors have been the topic of many recent reviews. These reviews provide a good summary of much of the relevant literature--including the older literature. We have, therefore, chosen to focus the present review on the insights gained from recent studies on genetically modified mice, particularly with respect to the function of adenosine receptors and their potential as therapeutic targets. The information gained from studies of drug effects is discussed in this context, and discrepancies between genetic and pharmacological results are highlighted.

[Indexed for MEDLINE]

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