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Nat Rev Microbiol. 2005 May;3(5):421-9.

Ashbya gossypii: a model for fungal developmental biology.

Author information

1
Junior Research Group, Growth-control of Fungal Pathogens, Hans-Knöll Institute for Natural Products Research, Department of Microbiology, Friedrich-Schiller University, Hans-Knöll Strasse 2, D-07745 Jena, Germany. juergen.wendland@uni-jena.de

Abstract

Ashbya gossypii is a riboflavin-overproducing filamentous fungus that is closely related to unicellular yeasts such as Saccharomyces cerevisiae. With its close ties to yeast and the ease of genetic manipulation in this fungal species, A. gossypii is well suited as a model to elucidate the regulatory networks that govern the functional differences between filamentous growth and yeast growth, especially now that the A. gossypii genome sequence has been completed. Understanding these networks could be relevant to related dimorphic yeasts such as the human fungal pathogen Candida albicans, in which a switch in morphology from the yeast to the filamentous form in response to specific environmental stimuli is important for virulence.

PMID:
15821727
DOI:
10.1038/nrmicro1148
[Indexed for MEDLINE]

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