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Fertil Steril. 2005 Apr;83(4):959-63.

Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss.

Author information

1
Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Patriarhou Grigoriou 97-99, Alexandroupolis 68100, Greece. dapap@otenet.gr

Abstract

OBJECTIVE:

To investigate whether four common polymorphisms (-2578C/A, -1154G/A, -634G/C, and 936C/T) of the gene encoding for vascular endothelial growth factor (VEGF) are associated with idiopathic recurrent miscarriage.

DESIGN:

Prospective case-control study.

SETTING:

University teaching hospital.

PATIENT(S):

Fifty-two patients with a history of three or more unexplained consecutive pregnancy losses and 82 healthy, postmenopausal controls with at least two live births and no history of pregnancy loss.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the different VEGF alleles.

RESULT(S):

There was a significant difference in the -1154G/A genotype and allele frequency between women with recurrent pregnancy loss and controls. The risk of recurrent pregnancy loss was lower in the carriers of the G allele than in women carrying the A allele (odds ratio = 1.91, 95% confidence interval, 0.12-3.28). No significant association between recurrent spontaneous abortions and -2578C/A, -634G/C, and 936C/T genotypes was found. Between women with primary and secondary idiopathic recurrent miscarriage, no statistically significant differences with respect to allele frequencies were observed.

CONCLUSION(S):

This is the first report on VEGF gene polymorphisms in women with recurrent miscarriage, demonstrating that the -1154G/A VEGF gene polymorphism is associated with idiopathic recurrent abortions.

[Indexed for MEDLINE]

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