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Fertil Steril. 2005 Apr;83(4):897-901.

Efficacy of in vitro fertilization after chemotherapy.

Author information

1
Department of Gynecology, Université Catholique de Louvain, Cliniques Universitaires St. Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium.

Abstract

OBJECTIVE:

To evaluate if in vitro fertilization (IVF) with embryo cryopreservation can be proposed to patients immediately after one or two regimens of chemotherapy.

DESIGN:

Retrospective study.

SETTING:

Academic research center and IVF unit.

PATIENT(S):

Eleven young patients diagnosed with cancer between September 1999 and April 2003 who wanted to preserve their fertility via IVF.

INTERVENTION(S):

Stimulation and IVF before or soon after chemotherapy treatment.

MAIN OUTCOME MEASURE(S):

The number and quality of embryos obtained after stimulation in cancer patients undergoing IVF before or soon after chemotherapeutic treatment.

RESULT(S):

Four patients underwent IVF in the interval between two regimens of chemotherapy. Two of them had no follicular development; one underwent follicular puncture but no oocytes were retrieved; and, in one, six oocytes were harvested but only one good quality embryo was obtained. In the seven patients who underwent IVF before starting chemotherapy, between 4 and 11 embryos were obtained per patient, the majority being good quality embryos.

CONCLUSION(S):

Because the efficacy of IVF is dramatically reduced after even one round of chemotherapy, IVF should be performed before chemotherapy. For those who require immediate chemotherapy, ovarian tissue cryopreservation and/or oocyte cryopreservation could be used before treatment.

[Indexed for MEDLINE]

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