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Cell. 2005 Apr 8;121(1):9-12.

Melanocyte stem cell maintenance and hair graying.

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1
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.

Abstract

Hair graying is an obvious sign of human aging, yet little was known about its causes. Two recent papers provide compelling evidence that hair graying is due to incomplete melanocyte stem cell maintenance and identify Pax3 and Mitf as key molecules that help regulate the balance between melanocyte stem cell maintenance and differentiation.

PMID:
15820674
DOI:
10.1016/j.cell.2005.03.021
[Indexed for MEDLINE]
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