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Cell Calcium. 2005 May;37(5):433-42.

Temporal integration of intracellular Ca2+ signaling networks in regulating gene expression by action potentials.

Author information

1
Nervous System Development and Plasticity Section, National Institutes of Health, NICHD, Bldg. 35, Room 2A211, MSC 3713, 35 Lincoln Drive, Bethesda, MD 20892, USA. fieldsd@mail.nih.gov

Abstract

Temporal aspects of intracellular calcium signaling are particularly important in activity-dependent regulation of gene expression in neurons. This review traces calcium-dependent intracellular signaling from the membrane to the nucleus in response to action-potential firing, and considers how specific genes are regulated by specific patterns of impulse firing. Modes of calcium influx, calcium-dependent protein kinases, transcription factors, individual genes, and genomic analysis are examined, with particular emphasis on the importance of temporal aspects of calcium dynamics in regulating these processes.

PMID:
15820391
DOI:
10.1016/j.ceca.2005.01.011
[Indexed for MEDLINE]

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