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Am J Cardiol. 2005 Apr 15;95(8):973-5.

Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction.

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Department of Medicine, Michigan State University, East Lansing 48824, USA. <>


The hypothesis that aspirin resistance is often due to noncompliance was investigated. One hundred ninety patients with a history of myocardial infarction were evaluated using arachidonic acid-stimulated light aggregometry at 3 different time points: while receiving their usual daily aspirin, after not receiving aspirin for 7 days, and 2 hours after the observed ingestion of aspirin 325 mg. At the first time point, 17 patients (9%) failed to show aspirin inhibition of platelet aggregation, but 2 hours after observed aspirin ingestion, aspirin inhibition was observed in all but 1 patient.

[Indexed for MEDLINE]

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