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BMC Infect Dis. 2005 Apr 8;5:24.

Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria.

Author information

1
Alfa Institute of Biomedical Sciences, Athens, Greece. matthew.falagas@tufts.edu

Abstract

BACKGROUND:

The increasing problem of infections due to multidrug-resistant Gram-negative bacteria has led to re-use of polymyxins in several countries. However, there are already clinical isolates of Gram-negative bacteria that are resistant to all available antibiotics, including polymyxins.

METHODS:

We present a case series of patients with infections due to pathogens resistant to all antimicrobial agents tested, including polymyxins. An isolate was defined as pandrug-resistant (PDR) if it exhibited resistance to all 7 anti-pseudomonal antimicrobial agents, i.e. antipseudomonal penicillins, cephalosporins, carbapenems, monobactams, quinolones, aminoglycosides, and polymyxins.

RESULTS:

Clinical cure of the infection due to pandrug-resistant (PDR) Gram-negative bacteria, namely Pseudomonas aeruginosa or Klebsiella pneumoniae was observed in 4 out of 6 patients with combination of colistin and beta lactam antibiotics.

CONCLUSION:

Colistin, in combination with beta lactam antibiotics, may be a useful agent for the management of pandrug-resistant Gram-negative bacterial infections. The re-use of polymyxins, an old class of antibiotics, should be done with caution in an attempt to delay the rate of development of pandrug-resistant Gram-negative bacterial infections.

PMID:
15819983
PMCID:
PMC1087841
DOI:
10.1186/1471-2334-5-24
[Indexed for MEDLINE]
Free PMC Article

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