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Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1135-41. Epub 2005 Apr 7.

Vascular implications of the Krüppel-like family of transcription factors.

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Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Japan.


The Krüppel-like factor (KLF) family is a recently highlighted group of zinc finger transcription factors given their important biological roles which include the vasculature. KLF2, KLF4, KLF5, and KLF6 are notable factors that have been implicated in developmental as well as pathological vascular processes. In this brief review, we provide an up-to-date summary of the physiological functions and cellular effects as well as transcriptional regulatory mechanisms of the vascular KLFs. Through such, we aim to provide a working view for understanding the pathological actions of KLFs in the vasculature.

[Indexed for MEDLINE]

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