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Am J Respir Crit Care Med. 2005 Jul 1;172(1):67-73. Epub 2005 Apr 7.

Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.

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1
Department of Human Genetics, University of Chicago, 920 East 58th Street, CSLC 507C, Chicago, IL 60637, USA.

Abstract

RATIONALE:

Recent genetic studies have implicated integrins in asthma and atopy susceptibility. We therefore evaluated the integrin-beta3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes.

METHODS AND MEASUREMENTS:

We genotyped and performed association tests on 19 single nucleotide polymorphisms in ITGB3 in the Hutterites, a founder population, and in three outbred replication populations.

MAIN RESULTS:

Variation in ITGB3 was strongly associated with susceptibility to bronchial hyperresponsiveness and protection from allergic sensitization to mold allergens in this population. Three independent case-control populations representing Caucasians and African Americans were used to replicate this finding, also revealing ITGB3 alleles that are associated with asthma susceptibility and protection from mold allergen sensitization.

CONCLUSIONS:

This study provides evidence that ITGB3 plays a role in the pathogenesis of asthma and sensitization to mold allergens.

PMID:
15817799
PMCID:
PMC2718448
DOI:
10.1164/rccm.200411-1555OC
[Indexed for MEDLINE]
Free PMC Article
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